Recent publications: Michael DeGiorgio investigates the effects of geographic sampling

Mol Biol Evol. 2012 Oct 10. [Epub ahead of print]

Geographic sampling scheme as a determinant of the major axis of genetic variation in principal components analysis.

Degiorgio M, Rosenberg NA.
*Department of Integrative Biology, University of California, Berkeley, CA 94720, USA.

Abstract
Principal component (PC) maps, which plot the values of a given PC estimated on the basis of allele frequency variation at the geographic sampling locations of a set of populations, are often used to investigate the properties of past range expansions. Some studies have argued that in a range expansion, the axis of greatest variation (i.e., the first PC) is parallel to the axis of expansion. In contrast, others have identified a pattern in which the axis of greatest variation is perpendicular to the axis of expansion. Here, we seek to understand this difference in outcomes by investigating the effect of the geographic sampling scheme on the direction of the axis of greatest variation under a two-dimensional range expansion model. From datasets simulated using each of two different schemes for the geographic sampling of populations under the model, we create PC maps for the first PC. We find that depending on the geographic sampling scheme, the axis of greatest variation can be either parallel or perpendicular to the axis of expansion. We provide an explanation for this result in terms of intra- and inter-population coalescence times.

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